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Typically after a steroid cycle it can take several weeks or months for endogenous testosterone to return back to normal levelsin the body. After these periods of testosterone inactivation can extend some cycles to as long as three months. This is because testosterone can cross the blood-brain barrier faster than the testosterone inactivity. Although testosterone was found to stimulate neuronal growth in some male model systems, and the testosterone-growth effect cannot be assumed to be constant across the human male, it does appear to be slightly higher than in the non-hormone-free control group. This can be attributed to the activation of androgen specific transcription factors within cells which can suppress the transcription of genes involved in androgen receptor regulation. Athletic performance and testosterone levels Men tend to feel more confident when running and jumping more during an elevated testosterone state. In comparison men running in a control state showed a lack of testosterone enhancement. However, since the study did not consider how many of the subjects were able to run for a longer distance than they had to in an optimal or a performance state, it is not clear if the increased testosterone levels produced by the testosterone boost can fully compensate for the reduced time spent running. The effect of higher testosterone levels on running is likely to be of a positive nature. In women, there is a link between increased circulating testosterone and enhanced energy reserve, improved cardiovascular fitness and lean body mass, and increased muscle mass. Men are more active than women which, as a result, would suggest that increases in testosterone may be beneficial through providing benefits to physical power. However, men are also a less competitive gender than women, which may prevent men from taking advantage of their increased testosterone levels. Furthermore, women have their natural testosterone levels maintained by ovulation and natural hormone production, which would make them less sensitive, even over time, to any increases in testosterone levels. Testosterone has some negative effects on performance, particularly in sprinting. Men can suffer reductions in aerobic power and muscular endurance due to increased testosterone. For instance, in men testosterone levels were shown to drop up to 16% in a 10-week period. However, more research shows that the increase in testosterone, despite its negative impact on physical ability, may be beneficial for sports performance in other ways, notably with the immune system. These effects are due to the increased availability of sex hormones through increased circulation and increased activity by the body. It should be noted that the research on testosterone effects on athletic performance has been conducted on laboratory animals. In humans testosterone does not appear to have an effect on performance in non-human primates. This is largely due to the Similar articles: